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For example, the potent anti-inflammatory effects (Section 4.1) that shift microglia to a reparative M2 phenotype may be a direct prerequisite for effective remyelination (Section 4.3), as pro-inflammatory M1 microglia are known to inhibit oligodendrocyte progenitor cell (OPC) differentiation

Cerebrovascular reactivity, the ability of the cerebral vasculature to increase local blood flow via arteriole dilation in response to neural activity, is impaired in MS, perhaps as a result of vascular desensitization from chronic high levels of nitric oxide stemming from inflammation [144]

Simpson said people with active cancer or a history of tumors are especially at risk