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and Isabelle Raymond, PhD
Isoflavones displace testosterone and 17- estradiol from sex hormone-binding globulin (sHBG) sites and control the levels of aromatase, 5- reductase, and plasma sHBG
The KD may be most effective when microbiota integrity is preserved through targeted fiber reintroduction, probiotic support, or cyclical carbohydrate inclusion to sustain SCFA levels and mineral uptake
Second, many available studies are characterized by small sample sizes or lack appropriate control groups, making it difficult to draw definitive conclusions about therapeutic efficacy and optimal treatment protocols
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