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Moreover, in vivo experiments using a B16F10 mouse melanoma model demonstrated that injection of pDox + RA@adipocytes significantly delayed tumor growth, accompanied by increased infiltration of CD4 + and CD8 + T cells into the tumor tissue and a reduction in the number of Tregs

found that carnitine supplementation modified the production of various cytokines, such as interferon-, tumor necrosis factor-, interleukins-2, 4, 6, vascular endothelial growth factor, granulocyte-macrophage colony stimulating factor, and insulin-like growth factor-1 in serum and peritoneal fluid as tested using the immunofluorescence or ELISA technique [19]

doi: 10.1016/j.ejmech.2020.112675 10 BlancWARosenblattPWolffJA