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A secondary effect of this stress is activation of Nrf2 and its target genes resulting in compensatory higher GSH levels and induction of antioxidant genes in the livers of these mice, which makes these livers more resistant to additional acute stress such as APAP toxicity [151]

Han et al., 2016)

2.5 Traditional herbal medicine meets network science Network pharmacology is particularly suitable for analyzing traditional herbal formulas, which contain multiple components acting on diverse biological targets

Across the available tablet data, around 7-8% of patients stopped treatment because of side effects , compared with around 3-6% of patients taking placebo