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Recent evidence suggests that this temporal regulation involves not only the hypothalamicpituitaryadrenal axis but also mesolimbic reward pathways, where circadian fluctuations in monoaminergic neurotransmission (particularly dopamine and serotonin) influence endocrine responses to environmental cues (116, 117)

doi: 10.1007/s11096-015-0134-z 43

however, the rate of hospitalisation for heart failure was increased

A Cox proportional hazards model was utilized to estimate hazard rate ratios (HR) for MOF, and survival curves were plotted using the Kaplan-Meier estimator