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Combination therapy research with GLP-1 agonists

Trials show body weight reductions exceeding 22% at the highest dose (12mg/week), with its efficacy shown to be superior to Semaglutide across multiple study designs

We previously reported that antibodies against phosphoenolpyruvate carb kinase and proprotein convertase subtilisin/kexin type 9 are increased in patients with diabetes and associated with poor prognoses 2,3

The honest way to hold this fact is in two hands at once: the causal link was not proven, and the episode is nonetheless a real part of why the DAC form never advanced and why the compound class is treated with caution