GLP-1 medications cause sulfur burps and bloating by slowing gastric emptying , which keeps food in the stomach longer and increases pressure and post-meal discomfort, especially after larger or higher-fat meals. Scientific explanation delayed gastric emptying and pyloric tone GLP-1 receptor agonists reduce gastric motility and increase pyloric sphincter tone , delaying the passage of solid food from the stomach into the small intestine
People at Risk The risk of adverse effects is especially high in people with [70+]: Digestive conditions (Crohns disease, ulcerative colitis, diverticulitis) A history of bowel surgery Severe hemorrhoids Kidney, heart, and liver disease Allergy to coffee The FDA only approves colon cleansing to prepare for medical procedures and has issued several letters warning about unapproved uses
The evidence base for this combination is early-stage, primarily observational, but a 2015 randomized trial in Thrombosis and Haemostasis (N=244) found MK-7 supplementation slowed progression of arterial stiffness in healthy postmenopausal women over 3 years [13]
People will have to be on these drugs long-term or the weight will come back on, says Charlie Seltzer, MD , a board-certified obesity medicine doctor in Philadelphia
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