vitamin c regenerates glutathione The main mechanisms of action of (ascorbic acid) Role of glutathione in antioxidant

The 3D structure and 2D interaction map reveal numerous - stacking, -alkyl, and hydrogen bond interactions with residues around the active site

The similarity in changes in GCL activity in the liver with the rebound increase in ELF GSH also point to the liver as a potential source for this GSH

[40] Mechanism [edit] Drugs continue to be taken off the market due to late discovery of hepatotoxicity

What NAPQI does: Directly binds to and damages cellular proteins Depletes glutathione rapidly Generates oxidative stress which damages DNA Triggers cell death Damages mitochondria, disrupting energy production NAPQI crosses the placenta and depletes fetal brain glutathione at doses below those causing maternal liver toxicity