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This deuterium exchange is in contrast to surrounding amides, which exchange very little if any deuterium after 30 s, and is evidence of a thermodynamically weaker hydrogen bond at this amide

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Impaired transport function and composition integrity of the brain endothelium results in BBB injury in diabetes, which is related to hyperglycemia, chronic inflammation, and oxidative stress

The nuclear translocation of activated AKT induced the phosphorylation of FoxO proteins which evoked the 14-3-3-mediated export of FoxO proteins from the nuclei