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This section explores potential future developments, research priorities, and clinical applications of GLP-1-based therapies for adolescent obesity

doi: 10.1038/s41467-020-14959-w 5 ArvanitakisZ.CapuanoA

In a Phase 2b study in people with type 2 diabetes and obesity over 54 weeks, treatment with cotadutide at doses of 100-300 g daily improved some non-invasive markers of NAFLD such as transaminase levels, the FIB-4 index, fatty liver disease fibrosis score (NFS) and fatty liver index (FLI) but fatty liver disease was not assessed directly with liver biopsy

These controls allow researchers to accurately attribute observed effects to the combined stack and differentiate true synergy from additive effects or individual peptide contributions