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Among these mechanisms, the anticancer potential of CHE was evaluated in human melanoma A-375 and SK-MEL-2 cell lines, where the drug was found to facilitate cell apoptosis by suppressing the expressions of antiapoptotic proteins (Bcl-xL, Mcl-1, and XIAP), decreasing mitochondrial membrane potential, and cleaving caspase-3 and PARP

Several approaches including epigenetics, postmortem studies, and measurement of GABA level in cerebrospinal fluid and plasma have been used to unravel the role of the GABA system in the pathophysiology of psychiatric disorders (131)

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