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The drug was the worlds bestseller until the COVID-19 pandemic stoked demand for the Pfizer-BioNTech vaccine, whose cumulative annual sales hit $59.1 billion in 2021

PT-141 and PDE5 inhibitors work through completely different mechanisms and can be safely combined

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After repeated administration, rats in the short-access paradigm exhibited lower daily and cumulative METH intake than saline controls, with this effect becoming apparent on the second day of treatment and continuing throughout the study, while LIR did not affect METH-taking behavior in the extended-access paradigm