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226 Although it is still unclear whether hearing loss is the cause of changes in brain structure and function, intriguing evidence has shown individuals with prolonged hearing loss experience shrinkage of certain brain regions

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The energy requirements of the brain are very high due to energy intensive processes that are essential for healthy brain function, such as maintenance of ion gradients, cellular signalling, synaptic vesicle trafficking, and uptake and recycling of neurotransmitters [190]

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