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For example, aspartic acid (Asp) may rearrange in the peptide chain, creating a different bond with nearby amino acids

Elife 9 , e52694 (2020)

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Although the large intestine has received a majority of attention in the opioid-induced constipation research field, with studies showing MOR activation in the large intestine during opioid-induced constipation 7 , our study implicates the small intestine is also a critical site for morphine-induced constipation