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Where indicated, a subset of subjects were instructed to continue with their current diet but, in addition, were placed on oral l-carnitine supplement (500 mg l-carnitine tartrate daily) and rechallenged in follow-up visits at 1 month and 23 months from baseline

Karagiannis T, et al

Typical Duration and Design of Studies on MSM Long-term studies typically involve a randomized, double-blind, placebo-controlled design to ensure reliability and minimize bias

Most shedding of this kind recovers once the trigger settles and any shortfall is corrected, so the goal of testing is to find the fixable pieces, read them together, and track the trend