Unfortunately, only a few studies examined whether the observed antioxidative effects and mitigation of symptoms of AP and CP result from an exclusive stimulation of Nrf2 pathway (Xu et al
These transporters primarily consist of solute carrier family 1 member 5 (SLC1A5, namely alanine serine and cysteine transporter system 2, ASCT2), SLC38A1 (sodium-coupled neutral amino acid transporters 1, SNAT1) and SLC38A2 (sodium-coupled neutral amino acid transporters 2, SNAT2), with ASCT2 being the most important (14, 15)
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In addition, capsaicin (CAP), another gut microbiota metabolite, alleviates ventilator-induced lung injury by activating Sirtuin 3 (SIRT3) to inhibit ferroptosis and maintain mitochondrial redox homeostasis (129)
