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Supplemental Material Tables S1S3 Supplementary Material Nonstandard Abbreviations and Acronyms ACC American College of Cardiology AHA American Heart Association BMI body mass index BP blood pressure CagriSema cagrilintide/semaglutide DBP diastolic blood pressure ETD estimated treatment difference GLP-1RA glucagon-like peptide-1 receptor agonist HbA 1c glycated hemoglobin HDL high-density lipoprotein SBP systolic blood pressure For Sources of Funding and Disclosures, see page 430

The identity of the batch is determined by sequence and mass confirmed by mass spectrometry at COA

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Vegetarians and vegans, because Acetyl-L-Carnitine is an amino acid mainly in animal muscle meats, mostly red meat Some individuals also have a genetic modification that prevents the body from producing L-carnitine Others with medical conditions, such as Crohns disease, who have trouble absorbing nutrients could also be L-carnitine deficient Elderly individuals: studies have also shown that as one ages, L-carnitine production also reduces Newborns are usually screened for a condition called primary carnitine deficiency