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From nine rats of each group, gingivomucosal tissue samples were collected from both the ligature and the non-ligature contralateral sides and vascular permeability was measured as described in Materials and Methods

The mechanism of this combined effect appears to be sequential: TB-500 mobilizes and migrates repair cells to the injury site (via actin regulation and chemotactic signaling), while BPC-157 creates the optimal local microenvironment (via angiogenesis, growth factor expression, and NO modulation) for those cells to perform effective repair once they arrive

In naturally aged mice, the renal function improvements were statistically significant but more modest a pattern consistent with the lower but still meaningful senescent cell burden in normal aging