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While the body of literature is substantial, it's important to acknowledge that much of it originates from a single research group, and independent replication remains limited

If it looks fine but the date has passed, still do not use it

The animal science is real, but calling it 'proven' is a stretch when 99.7% of the research is in rats

Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)