Meanwhile, in January 1996 the first rodent study suggested that GLP-1 could be a central regulator of feeding behavior and satiety based on intracerebroventricular injection studies [4], but soon thereafter the results of other rodent studies using peripherally injected GLP-1 argued against an appetite effect [5]
The predominance of liraglutide in this study suggests that prescribers prioritize familiarity and established efficacy when selecting GLP-1 receptor agonists
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Table 8: Results at Week 26 in a Trial Comparing TRESIBA to Insulin Detemir in Pediatric Patients 1 Year of Age and Older with Type 1 Diabetes Mellitus Receiving Insulin Aspart at Mealtimes The change from baseline to end of treatment visit in HbA1c was analyzed using ANOVA with missing data imputed by multiple imputation carrying forward the baseline value and adding the error term, with treatment, region, sex, and age group as fixed factors, and baseline HbA1c as covariate
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