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About 25% of recreational endurance athletes have elevated homocysteine. People with blood pressure needs : Elevated homocysteine impairs nitric oxide synthesis

In general, the mitochondrial reduced:oxidised ratio is greater than that of the cytosol, resulting in a more reducing environment in the mitochondria (reflecting the high degree to which reactive oxygen species are produced within mitochondria)

Study: Impaired striatal glutathioneascorbate metabolism induces transient dopamine increase and motor dysfunction