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Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]

Patients should increase fiber gradually over 2-3 weeks to minimize gas and bloating, which can be particularly problematic given semaglutide's effect on gastric emptying

Retatrutide is commonly described as a triple GIP, GLP-1, and glucagon receptor agonist

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