A follow-up review in Nutrients (2023) elaborated on the mechanistic pathway: intestinal NAD+ biosynthesis, via the AMPKNAMPTSIRT1 axis, is critical for maintaining the gut environment that produces GLP-1
Where excess skin or genuine diastasis recti are present, non-surgical treatments offer mild improvement, and surgery liposuction, tummy tuck, or a combination is the only treatment that fully resolves significant skin excess or muscle separation
Body composition (particularly muscle mass), thyroid function, physical activity levels, sleep quality, and dietary protein intake have more substantial effects on metabolic rate than injectable medications
Build a small "GLP-1 shelf" at home (single-serve yogurts and cottage cheese, pre-portioned nuts, canned tuna, a tub of chia seeds, and a fiber-rich whole-grain cracker) and prep on the weekend so you're never stuck reaching for something that won't sit well