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17 In 1987, phlorizin was found to alleviate hyperglycemia and restore insulin sensitivity in rats with diabetes, indicating its potential for T2D treatment

In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]

If changes to food composition are not enough, setting an alarm or other reminder to eat can be helpful

Healthcare professionals should provide comprehensive counselling about realistic expectations, potential side effects, and the importance of lifestyle modifications alongside pharmacotherapy for optimal outcomes in cardiometabolic health