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Similarly, in mesangial cells, GLP-1 receptor agonists have been shown to suppress either high-glucose-induced or AGEs-induced pro-fibrotic signalling pathways, including NF-B activation and TGF-1 expression, leading to reduced ECM deposition [60,61], and to suppress their proliferation via AMPK activation [62]

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Summary: Mounjaro (tirzepatide) is not directly associated with orthostatic hypotension, but weight loss, gastrointestinal side effects causing dehydration, and interactions with concurrent medications may contribute to postural blood pressure changes in susceptible patients