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Although methylfolate increases the formation of serotonin, it also promotes the expression of SERT through the demethylation of histones that are already methylated, thereby inhibiting the function of serotonin

Studies have shown that B-12 injections can improve behavioral and cognitive function in individuals with autism

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Highdose IV protocols (5001,500 mg daily for ~10 days) have been used in openlabel studies for substance use disorder, with reports of reduced cravings and improved mood in followups [2] [9]