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Looking beyond longevity
Dual-pathway agents like tirzepatide, which activate both GLP-1 and GIP receptors, demonstrate superior outcomesup to 20% weight losscompared to semaglutide alone
Inhibitory effect of methotrexate on rheumatoid arthritis inflammation and comprehensive metabolomics analysis using ultra-performance liquid chromatography-quadrupole time of flight-mass spectrometry (UPLC-Q/TOF-MS)
In the STEP-1 trial, 1,961 patients were followed for 68 weeks and underwent randomization to semaglutide or placebo plus lifestyle intervention resulting in14.9% weight loss in the semaglutide group versus 2.5% in the placebo group [33]
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