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Exclusion criteria The presence of serious somatic disorders, substance abuse except for cigarettes and caffeine, and history of high mood (mania or hypomania), mental dysfunction, dementia, acute psychiatric disorders according to the psychiatrist, and medication that causes depression in the patient were excluded from the study

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A specific role for IGF-1 receptor (IGF-1R) signaling in the mediation of mammalian longevity was first established in IGF-1R haploinsufficient mice, which lived 33% longer than controls, but unlike other models of reduced somatotropic signaling, this effect was female specific 6

The standard escalation protocol follows a gradual titration to minimize side effects while allowing the body to adapt