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This agrees with the previous reports where Spirulina supplementation reduced IL-6 expression and systemic inflammation [20, 93, 94]

Experimental domains include: In vitro cell line assays for endothelial activation, fibroblast migration, and gene transcription profiling Ex vivo tissue matrix systems assessing ECM deposition and angiogenic factors In vivo preclinical models exploring coordinated inflammatory suppression and accelerated wound closure rates By merging these peptides into a single formulation, researchers can evaluate both synergistic and divergent effects within unified experimental protocols eliminating the need for separate dosing strategies

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Shanghai Top Priority Research Center Project (2023ZZ02013)