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For example, a meta-analysis found that two copies of the MTHFR C677T variant (A/A, homozygous) increase the relative risk of heart disease by 38%.[ref][ref] However, not all studies agree, and a large prospective study (n=6,000) found that older people with two copies of the C677T allele were at a 30% decreased risk of death from cardiovascular disease when other parameters were included.[ref] The increased risk is not just due to high homocysteine

Currently, it afflicts approximately 9% to 10% of the population throughout the world, representing a high economic burden [4]

IV formulations carry infection and vein irritation risks if administered without proper medical oversight

In patients with early PD, the GLP-1RA lixisenatide can modestly slow the progression of motor dysfunction over 12 months of treatment, but it is associated with gastrointestinal side effects, and its long-term efficacy and safety require further verification (265)