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A systematic review and meta-analysis published in Diabetes, Obesity and Metabolism examined inflammatory markers across multiple GLP-1 receptor agonist trials and found reductions in hs-CRP levels, though the magnitude and clinical significance of these changes varied across studies

Insurers also introduced novel metabolic health programs: for instance, in 2026 CVS Caremark announced a Weight Management UM Bundle to automatically apply evidence-based PA criteria on new GLP-1 agents, reducing ad-hoc appeals ( [34] ) ( [35] )