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Another early investigation published in the European Journal of Endocrinology documented that, unlike older GH-releasing peptides, such as GHRP-2 or GHRP-6, ipamorelins GH stimulation is highly selective and does not significantly increase cortisol or prolactin levels, suggesting a cleaner hormonal profile with fewer off-target endocrine effects compared to earlier secretagogues

This segment serves a broad therapeutic base including vaccines, hormone therapies, anticoagulants, and a range of small molecule injectables where passive needle safety features are not mandated by the applicable regulatory or institutional formulary framework

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Following treatment discontinuation (after 2 years, or earlier due to non-response or adverse events), treatment effects were assumed to decline according to a catch-up rate until BMI returned to baseline