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An imbalance in these neurotransmitters is considered a major factor in depression (Qizilbash et al., 2022) a mouse model of allergic rhinitis, naringenin has been shown to significantly reduce the levels of serum IgE, IL-4, and IL-5, thereby ameliorating the symptoms of allergic rhinitis (ahin et al., 2021) anti-tumor research, it has been shown to effectively inhibit lung cancer cell proliferation through increased reactive oxygen species (ROS) production and activation of the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway