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Plus, less affinity of IGF-1 Des to bind with plasma IGFPB results in its increased clearance from the body

1.4 g 0.94 g

doi: 10.1038/s41467-023-44057-6

Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above