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Deferoxamine, the first FDA-approved drug in 1968 (Parker et al., 2023), is administered via intravenous (IV) or intramuscular (IM) injection due to its poor oral bioavailability, which is one of the most significant limitations of the DFO treatment ( A = 4 10 16 ) allows it to be the standard of care for acute iron toxicity for decades (Maggio et al., 2011)

While AOD9604 has not achieved the commercial success initially envisioned, it has contributed valuable insights into the dissociable functions of different regions of the growth hormone molecule and has validated the concept that targeted metabolic effects can be achieved without unwanted growth hormone receptor activation

[7] If patients are already taking biotin supplements, they should inform their clinician