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3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

The reduced enzymatic activity increases cellular concentrations of both substrates that NNMT would otherwise consume: S-adenosyl-L-methionine (the universal cellular methyl donor) and nicotinamide (the NAD + salvage precursor)

Glucose-6-phosphate dehydrogenase (G6PD) deficiency: High doses of vitamin C in CB 12 injection could cause hemolysis, a condition where red blood cells are destroyed prematurely, in patients with G6PD deficiency