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Indeed, recent studies using magnetic resonance imaging (MRI) to measure myelin water fraction suggest that obesity, along with conditions like hypertension and metabolic syndrome, is linked to reduced myelin content in the brain ( 2.7 Endoplasmic reticulum stress Endoplasmic Reticulum (ER) stress is a condition that arises from the abnormal buildup of misfolded and unfolded proteins within the ER lumen