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36 (Suppl 1): S2935

Finally, we also assessed the capacity of the triple AA phospho-null mutant receptor to recruit GRK2 downstream of GLP-1 stimulation and we again observed a significant loss of in the recruitment of this kinase in the mutant versus the WT receptor (Fig

Importantly, Willard and colleagues (JCI Insight, 2020) demonstrated that tirzepatide is a biased agonist at GLP-1R, favouring G protein signalling over -arrestin recruitment, a property that may attenuate receptor desensitisation during chronic exposure