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10.1016/j.pbb.2013.09.002 56 MohamedE

Deletion of Lepr in POMC neurons alone alters energy expenditure, glucose tolerance and hepatic insulin sensitivity, without affecting body weight [123, 127], whereas Insr deletion in POMC cells causes insulin insensitivity in the adipose tissues suppressing lipolysis, but without affecting energy balance [128]

Patients report improved skin elasticity, reduced fine lines, and thicker hair over 3 to 6 months of therapy

Common missteps like skipping doses, neglecting proper nutrition, stopping too soon, extreme calorie restriction, or going it alone without guidance can derail your progress