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Follicular fluid IGF concentrations correlate with oocyte competence

By activating autophagy or large tumor suppressor kinase (LATS)/yes-associated protein (YAP)/connective tissue growth factor (CTGF, also known as CCN2) signaling, irisin can help maintain cellular activity and matrix metabolism balance and inhibit inflammatory effects, thereby decelerating the progression of IVDD (115, 117)