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Phukan T, Syiem MB

Copper is an essential trace mineral involved in numerous enzymatic reactions, including those governing: collagen crosslinking antioxidant defense connective tissue formation mitochondrial respiration When bound to copper, GHK acts as a carrier molecule that delivers bioavailable copper to cells while simultaneously triggering regenerative signaling pathways

Our work herein identifies a key role for MC-derived histamine release and subsequent H4R activation in driving clinical and histopathologic severity in UC-like inflammation by regulating innate neutrophil recruitment and associated mucosal injury, likely via coordinating the downstream local production of IL-6 and neutrophil-attracting chemokines