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These included the Female Sexual Function Index (FSFI), a comprehensive 19-item self-assessment measuring desire, arousal, lubrication, orgasm, satisfaction, and pain, with higher scores indicating better function

Current legal status As of early 2026, the situation remains fluid

This dysfunction manifests as reduced vascular response to dilators (particularly to NO and prostacyclin), heightened pro-inflammatory responses leading to vascular wall inflammation, increased oxidative stress contributing to vascular damage, and pathological changes

Commercial GHK-Cu serums typically claim 6-12 month shelf life unopened when properly formulated with preservatives and appropriate pH, dropping to 3-6 months after opening due to air exposure and contamination introduction