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Phase III (Confirmation): Large-scale studies (1,0003,000+ patients) to compare the new treatment against existing standards

On the diagnostic side, the establishment of a composite ferroptosis activity scoreintegrating lipid peroxidation products, iron metabolism indices, and ferroptosis-associated non-coding RNAs through machine learning frameworkscould enable patient stratification, disease monitoring, and prediction of therapeutic response

Neither the murine mu-class nor pi-class GST can detoxify activated AFB 1 and all the activity towards this substrate is contributed by the alpha-class GST