2 Low-resolution techniques in the discovery of IDPs Although the role of NMR in understanding the dynamic nature of IDPs/IDRs and characterization of their conformational ensembles is undeniable and it illuminates intrinsic disorder (Dyson and Wright, 2021), very important information, especially in the early days of the IDP field, was derived using a wide spectrum of low-resolution techniques
Neurometabolites were quantified with LCModel [48], with prior reported chemical shifts and coupling constants [49, 50] as a basis for the model spectra of aspartate (Asp), ascorbate/vitamin C (Asc), glycerophosphocholine (GPC), phosphocholine (PC), creatine (Cr), phosphocreatine (PCr), -amino-butyric acid (GABA), glucose (Glc), glutamine (Gln), glutamate (Glu), glutathione (GSH), myo-inositol (myo-Ins), N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), phosphoethanolamine (PE), scyllo-inositol (scyllo-Ins) and taurine (Tau) were generated based on previously reported chemical shifts and coupling constants.by using GAMMA/PyGAMMA simulation library of VESPA for applying the density matrix formalism (Versatile Simulation, Pulses and Analysis 9)
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[DOI] [Google Scholar] 91.Ahmed M., Marrez D.A., Abdelmoeen N.M., Mahmoud E.A., Ali M.A.S., Decsi K., Tth Z
