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doi: 10.3389/fphar.2018.01107 Received 18 June 2018 Accepted 10 September 2018 Published 08 October 2018 Volume 9 - 2018 Edited by Luca Antonioli, Universit degli Studi di Pisa, Italy Reviewed by Ignacio Catalan-Serra, Norwegian University of Science and Technology, Norway