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Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models
The pattern of liver injury was hepatocellular with serum aminotransferase levels as high as several thousand U/L, while alkaline phosphatase levels tended to be normal or minimally elevated (less than 3 times ULN)
doi: 10.1093/lifemeta/loac035 236 TerlukMRKapphahnRJSoukupLMGongHGallardoCMontezumaSRet al
Mechanisms such as increasing cellular antioxidant enzymes, stabilizing membranes, supporting DNA and mitochondrial repair, and modulating inflammatory cytokines suggest that peptides target multiple pathways for more impact
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