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Quick Answer: Tirzepatide does not directly increase libido, but weight loss from the medication may improve sexual function through hormonal normalization and enhanced body image

By engaging glucagon-like peptide-1 (GLP-1), glucagon (GCG), and glucose-dependent insulinotropic polypeptide (GIP) receptors simultaneously, the drug may modulate blood glucose levels and energy balance

However, weight changes can still occur with Other antidepressants, such as serotonin-norepinephrine reuptake inhibitors ( What Are the Side Effects of Wellbutrin? Like other prescription medications, bupropion can cause side effects

Tirzepatide is currently licensed for type 2 diabetes in the UK (as Mounjaro), but does not yet have UK marketing authorisation specifically for weight management, and combination protocols are not part of current recommendations