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The demonstration of the GLP-1 receptor and its expression on the beta cells was of course consistent with its powerful insulinotropic effects (89) and was soon followed by a large number of cell biological studies of its effect on beta cell biology (90)

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These genomic changes not only affect coding sequences, but also involve non-coding sequences, such as regulatory elements and repetitive sequences (such as LTR elements and HERVs), leading to gene expression disorders, which in turn drive the occurrence and development of tumors

The answer, for any rational researcher, is zero