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Athough increase in liver size as measured by liver weight is correlated with microsomal enzyme induction, neither the degree or extent of hypertrophy nor the magnitude of the weight increase is correlated with the magnitude of the enzyme induction in rats, dogs, or monkeys (Amacher et al

and through replacement of amino acids with unnatural amino acids or peptoids

These approaches could maximize the benefits of dual agonism while personalizing treatment to individual patient needs