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Paul C, Cather J, Gooderham M, Poulin Y, Mrowietz U, Ferrandiz C,

Through NRF2-driven GSH synthesis, tumor cells are protected from oxidative stress, which contributes to chemotherapy resistance by reducing the cytotoxic effects of ROS generated during treatment

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The access to higher amounts of insulinotropic and IGF-1-raising foods (sugar, grains and dairy) occurred about 10,000 years ago during the Neolithic Revolution and was further augmented by the Industrial Revolution